CALORIMETER, MCS ISOTHERMAL TITRATION

The MCS-ITC is a micro-calorimetry system equipped with an isothermal titration unit, which allows ultrasensitive characterization of the thermodynamics of a reaction in solution by using the Isothermal Titration Calorimetry (ITC) technology. ITC is a thermodynamic technique that allows the study of interactions between molecules by measuring the heat released or absorbed by interacting molecules, which is proportional to the amount of binding occurring. From these measurements thermodynamic characteristics, binding constants (~103 – 108 M-1), and reaction stoichiometry can be determined. Since the heat of binding is a naturally occurring event, ITC technology does not require immobilization and/or modification of the reactants.